Effects of 2,4-Diacetylphloroglucinol on Aspergillus niger and its Potential Use as a Derepressor of Heterologous Genes in an Engineered System
Category: Research Poster
Author(s): Samuel Waggoner
Presenter(s): Samuel Waggoner
Aspergillus niger is a species of filamentous fungus that is commonly found throughout different mediums like water, soil, and decomposing matter. 2,4-Diacetylphloroglucinol (DAPG) is signaling molecule from bacteria that has been shown to affect the physiology of and inhibit growth of other species of Aspergillus. DAPG has also been shown to derepress genes controlled by a regulator, phlF. This research aims to examine and record the effects on A. niger growth when exposed to varying concentrations of DAPG in order to find a healthy equilibrium where DAPG can work as a derepessor of heterologous genes controlled by phlF and while not affecting fungal growth negatively.