Statistical Analysis of a Novel Model of Post-Traumatic Osteoarthritis
Category: Research Poster
Author(s): Hayley Stern, Katie Sikes, Bradley Nelson, Kelly Santangelo
Presenter(s): Hayley Stern
Posttraumatic osteoarthritis (PTOA) is a degenerative disease that affects 630 million people worldwide. Lage animal models, specifically in sheep, can take extensive periods of time to develop PTOA following surgical induction, which can delay preclinical testing and technology development for human treatment. The goal of this study was to evaluate a novel surgical model that involves transection of both the anterior cruciate ligament (ACL) and the long digital extensor (LDE) tendon, relative to previously established PTOA models including ACL transection alone and destabilization of the medial meniscus (DMM). After 12-weeks post-surgery, histological analysis demonstrated significant pathological between the three different models suggesting divergent degeneration pathways. Transection of both the ACL and LDE allows for a novel method for the study of PTOA disease progression for use in preclinical evaluations.